Alec Baldwin Cameron Diaz Abigail Breslin Thomas Dekker Joan Cusack Jason Patric Elizabeth Daily Sofia Vassilieva Evan Ellingson Heather Wahlquist David Thornton David Bortolucci Brennan Bailey Marcos A. Ferraez Nicole Marie Lenz Annie Wood Olivia Hancock Chris Kinkade Paul Butler Olivia Jade Fine Michael Bretten Rico Simonini Ryan Preimesberger Noni Tulk-Perna Krystal Grenseman Rick Crawford Mimi Fletcher Nina Barry Kaiulani Kimbrell Tom Beaver Andrew Shack
Sara and Brian Fitzgerald's life with their young son and their two-year-old daughter, Kate, is forever altered when they learn that Kate has Leukemia. The parents' only hope is to conceive another child, specifically intended to save Kate's life. For some, such genetic engineering would raise both moral and ethical questions; for the Fitzgeralds, Sara (Cameron Diaz) in particular, there is no choice but to do whatever it takes to keep Kate alive. And what it takes is Anna.